Lens Library

Inform and inspire your next study.

A showcase of analyses our research team built in Lens — biomarker discovery, outcomes research, and translational work across oncology. Explore them to inspire new approaches you can take with Lens.

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20
Published analyses
13
Oncology indications
100%
Reproducible in Lens
Library

More demonstrations from our team.

Analyses our research team ran in Lens across oncology indications and biomarkers. Each card opens the full write-up on tempus.com.

Ovarian CA125

Integrating CA125 and ctDNA to enhance prognostic precision in ovarian cancer

Combined clinical and molecular markers provide superior prognostic value in ovarian cancer.

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Breast · TNBC PIK3CA

Mutational profiles and treatment resistance in metastatic TNBC

Tempus Lens analysis identifies genomic markers of chemotherapy resistance in TNBC patients.

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Gastric CLDN18.2

Characterizing CLDN18.2 and HER2 expression in gastroesophageal cancer

Tempus RWD reveals CLDN18.2 and HER2 are independent biomarkers in gastroesophageal cancer.

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Lung · NSCLC IL33

IL33 expression as a predictor of immunotherapy response in NSCLC

High IL33 levels correlate with improved survival in specific NSCLC patient cohorts.

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Breast · HR+/HER2- ER Signaling

Stratifying HR+ HER2- breast cancer through ER signaling and G2/M molecular signatures

Molecular signatures improve patient stratification beyond standard IHC clinical markers.

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Colorectal MSI-H/dMMR

High WRN expression and immunotherapy outcomes in MSI-H/dMMR colorectal cancer

Determining the impact of WRN expression on immunotherapy response in MSI-H/dMMR CRC patients.

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Endometrial TP53

Prognostic impact of TP53 and PPP2R1A mutations in endometrial cancer

Analysis of RWD reveals survival outcomes for co-mutated endometrial cancer.

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Colorectal · mCRC

Developing a gene expression signature for first-line treatment in metastatic CRC

Tempus RWD identifies a signature predictive of bevacizumab response in CRC.

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Kidney · RCC M2 macrophages

Impact of M2-like macrophage infiltration on RCC immunotherapy outcomes

Tempus Lens analysis reveals how immune profiling enhances macrophage predictive value.

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Melanoma LAG3

LAG3 expression as a predictive biomarker for 1L ICI in melanoma

RWD analysis shows LAG3 expression predicts outcomes to different ICI regimens in melanoma.

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Lung · NSCLC EGFR

Predicting osimertinib outcomes in NSCLC using liquid biopsy RWD

ctDNA EGFR status predicts worse survival in NSCLC patients on osimertinib.

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Breast · HR+ MBC ESR1 · PIK3CA

Transcriptional and immune signatures of ESR1 and PIK3CA co-mutations in HR+ MBC

Discovery of distinct immunosuppressive microenvironments to guide combination therapies.

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Epithelial NUTM1

Identifying underdiagnosed NUT carcinoma with RWD

Real-world data reveals NUT carcinoma is frequently misdiagnosed, impacting outcomes.

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Breast · MBC HER2

Genomic and transcriptomic mediators of ADC resistance in breast cancer

RWD analysis reveals distinct resistance mechanisms for different ADCs in metastatic breast cancer.

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Head & Neck · HNSCC MET · HGF

HGF and MET expression predicts survival in HPV-negative head and neck cancer

Elevated HGF and MET expression correlates with worse survival in HNSCC patients.

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Prostate · mCSPC TSG

Defining high-risk mCSPC through tumor suppressor gene burden

RWD analysis quantifies the prognostic impact of TSG alterations in metastatic castration-sensitive prostate cancer.

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Pancreatic · PDAC KRAS

Evaluating KRAS mutant allele dosage impact on first-line PDAC outcomes

Higher mutant KRAS dosage linked to worse survival in PDAC patients treated with 1L therapy.

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Pan-Cancer KRASG12C

Genomic landscape of KRASG12C mutations across diverse tumor types

A large-scale RWD analysis of KRASG12C prevalence and associated biomarkers.

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Lung · LUAD Subtypes

Defining high-risk LUAD subtypes with large-scale RWD

RWD analysis identifies six LUAD subtypes, including a high-risk group with poor outcomes.

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Lung · SCLC Subtypes

Molecular subtyping of SCLC and its implications for personalized treatment strategies

Analysis identifies distinct SCLC subtypes with differential treatment responses.

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